The follow-up was conducted in 2015–2016 approximately six years after the baseline. The study had 706 patients who had a score of least 10 on the 21-item Beck’s Depression Inventory (BDI) Second Edition. The patients approached the nurse on their own or were referred by a general practitioner in 2008–2009 due to depressive symptoms. During data collection, new patients 35 years of age and older who had an appointment with a depression nurse case manager were eligible to enrol. The study has a catchment area of 274,000 residents. Subjects were enlisted from the primary health care services in the area of Central Finland Hospital District. The study (Finnish Depression and Metabolic Syndrome in Adults, FDMSA) was designed to enable the comparison of the sociodemographic, lifestyle, clinical and service utilization features of subjects without depressive symptoms, patients with depressive symptoms without clinical depression, and those with clinical depression. In particular, the importance of depression or depressive symptoms in the course of restless legs symptoms is not clear. However, there is not very much scientific knowledge about these associations based on longitudinal settings. Depression and depressive symptoms are associated with restless legs symptoms. The relationship between depression and restless legs symptoms is bidirectional but in previous prospective studies restless legs syndrome preceded both clinical depression and a new onset of depressive symptoms. Knowledge of the association between mood disorders and restless legs is not well established. prolactin and growth hormone), deficient dopaminergic neurotransmission, depression, genetics, systemic inflammation, peripheral hypoxia and iron deficiency. Previous studies have suggested that restless legs syndrome may be related to the lack of folate, hormones (i.e. The main theories explaining the pathophysiology of depression relate to monoamine neurotransmitters (serotonin and noradrenalin), neuroplasticity and neurogenesis. Psychiatric disorders, especially mood and anxiety disorders, and restless legs symptoms regularly exist together. They also have a negative and persistent influence on daily life. Restless legs symptoms increase the risk of self-harm and cardiovascular mortality. The prevalence of restless legs syndrome varies greatly between 3.5% and 36.8%. In addition, patients suffer from an urge to move their legs, and moving or stretching their legs relieves the symptoms. Symptoms of restless legs syndrome are characterised by an unpleasant sensations in the legs that occurs at rest in the evening or during the night.
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